Disease in a Dish Approach Could Aid Huntington’s Disease Discovery
Read the full article Disease in a Dish Approach Could Aid Huntington’s Disease Discovery at NeuroscienceNews.com.
Creating induced pluripotent stem cells or iPS cells allows researchers to establish “disease in a dish” models of conditions ranging from Alzheimer’s disease to diabetes. Scientists at Yerkes National Primate Research Center have now applied the technology to a model of Huntington’s disease (HD) in transgenic nonhuman primates, allowing them to conveniently assess the efficacy of potential therapies on neuronal cells in the laboratory.
The research is in Stem Cell Reports. (full open access)
Research: “Reversal of Cellular Phenotypes in Neural Cells Derived from Huntington’s Disease Monkey-Induced Pluripotent Stem Cells” by Richard L. Carter, Yiju Chen, Tanut Kunkanjanawan, Yan Xu, Sean P. Moran, Kittiphong Putkhao, Jinjing Yang, Anderson H.C. Huang, Rangsun Parnpai, and Anthony W.S. Chan in Stem Cell Reports. doi:10.1016/j.stemcr.2014.07.011
Image: The researchers induced the iPS cells to become neural progenitor cells and then differentiated neurons. The image is a scheme of the generation of induced pluripotent stem (iPS) cells, and is for illustrative purposes only. Credit Y tambe.
This approach to medicine causes animals to suffer, but manipulating and reprogramming stem cells holds serious promise in the search for cures.